Methenolone has no estrogenic side effects, and its effects on cholesterol levels are minimal. In doses of 200 mg per week or less (intramuscular) blood pressure is rarely altered. It is possibly one of the safer anabolic steroids for females due to very low Virilization effects in short-term usage. Methenolone is also not overly suppressive of the hypothalamic-pituitary-gonadal axis, although how suppressive is debatable. For this reason, many bodybuilders use it in between steroid cycles during their “off-time” to help maintain their gains and strength. The long term safety of such a practice is possibly dangerous and can lead to permanent suppression of the HPTA.