Approximately 70% of all human genes are expressed in colorectal cancer, with just over 1% of having increased expression in colorectal cancer compared to other forms of cancer.  Some genes are oncogenes : they are overexpressed in colorectal cancer. For example, genes encoding the proteins KRAS , RAF , and PI3K , which normally stimulate the cell to divide in response to growth factors, can acquire mutations that result in over-activation of cell proliferation. The chronological order of mutations is sometimes important. If a previous APC mutation occurred, a primary KRAS mutation often progresses to cancer rather than a self-limiting hyperplastic or borderline lesion.  PTEN , a tumor suppressor, normally inhibits PI3K, but can sometimes become mutated and deactivated. 
Hey guys, so my girlfriend decided to hop on Anavar and clen in a few weeks. She had a few questions for me, and I told her to do her research and come back to me with any questions she has. After both of us researching, she's going to be doing 32 days at 10 mg ED anavar, with the last 10 days being paired with 20mcg of clen. (low dose, first time using, and I don't want the sides to get too bad for clen so I put her on a low dose/low amount of days to test it out). Hopefully the clen doesn't react badly with depression/anxiety, which she is on medication for. I told her to hop off if shit gets rough though!