Approximately 70% of all human genes are expressed in colorectal cancer, with just over 1% of having increased expression in colorectal cancer compared to other forms of cancer.  Some genes are oncogenes : they are overexpressed in colorectal cancer. For example, genes encoding the proteins KRAS , RAF , and PI3K , which normally stimulate the cell to divide in response to growth factors, can acquire mutations that result in over-activation of cell proliferation. The chronological order of mutations is sometimes important. If a previous APC mutation occurred, a primary KRAS mutation often progresses to cancer rather than a self-limiting hyperplastic or borderline lesion.  PTEN , a tumor suppressor, normally inhibits PI3K, but can sometimes become mutated and deactivated. 
Effects of steroid withdrawal are known to emulate and kick start many other medical complications as well. Weakness, loss of appetite, fatigue, nausea, weight loss, vomiting, diarrhea (further resulting in liquid and electrolyte complications), as well as abdominal pain are some of the most common effects that steroid withdrawal is often associated with. Constant decrease in blood pressure which simultaneously causes a person to faint or causes fits and dizziness are other complications the steroid use can cause.
Blood sugar levels are known to have dropped in many people who consume steroids. In women, menstrual changes have been reported widely. Muscle and joint pains, fever, changes in mentality, as well as elevation in calcium levels have been reported in some cases. Gastrointestinal contractions decrease dramatically which may ultimately lead to the swelling of the intestine .
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