LABORATORY CONTROL: The PT reflects the depression of vitamin K dependent Factors VII, X and II. A system of standardizing the PT in oral anticoagulant control was introduced by the World Health Organization in 1983. It is based upon the determination of an International Normalized Ratio (INR) which provides a common basis for communication of PT results and interpretations of therapeutic ranges. 17 The PT should be determined daily after the administration of the initial dose until PT/INR results stabilize in the therapeutic range. Intervals between subsequent PT/INR determinations should be based upon the physician's judgment of the patient's reliability and response to Jantoven (warfarin sodium tablets) ® Tablets in order to maintain the individual within the therapeutic range. Acceptable intervals for PT/INR determinations are normally within the range of one to four weeks after a stable dosage has been determined. To ensure adequate control, it is recommended that additional PT tests be done when other warfarin products are interchanged with warfarin sodium tablets, USP, as well as whenever other medications are initiated, discontinued, or taken irregularly (see PRECAUTIONS ). Safety and efficacy of warfarin therapy can be improved by increasing the quality of laboratory control. Reports suggest that in usual care monitoring, patients are in therapeutic range only 33%-64% of the time. Time in therapeutic range is significantly greater (56%-93%) in patients managed by anticoagulation clinics, among self-testing and self-monitoring patients, and in patients managed with the help of computer Self-testing patients had fewer bleeding events than patients in usual care. 18
Oxymetholone is not recommended for women since it causes many and, in part, irreversible virilizing symptoms such as acne, clitorial hypertrophy, deep voice, increased hair growth on the legs, beard growth, missed periods, increased-libido, and hair loss. It is simply too strong for the female organism and accordingly, it is poorly tolerated. Some national and international competing female athletes, however, do take it during their “mass building phase” and achieve enormous progress. Women who do not want to give up the distinct performance-enhancing effect of Oxymetholone but, at the same time, would like to reduce possible side effects caused by androgen, could consider taking half a tablet (25 mg) every two days, combined with a “mild” injectable anabolic steroid such as Primobolan Depot or deca durabolin. Ultimately, the use of Oxymetholone and its dosage are an expression of the female athlete’s personal willingness to take risks. In schools of medicine Anadrol is used in the treatment of bone marrow disorders and anemia with abnormal blood formation.